Heterogeneity of packing: Structural approach
نویسندگان
چکیده
منابع مشابه
Internal packing and protein structural classes.
Protein folding is one of the most important and intriguing of the unsolved problems at the interface between chemistry and biology. The ability of polypeptide chains to fold into unique compact conformations with a vast array of biological functions is rare, if not unique, among high polymers. At this time there is no reason to believe that the chemical interactions currently recognized in sma...
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Extensive conformational heterogeneity is reported in highly refined crystallographic models for the proteins crambin, erabutoxin, myohemerythrin, and lamprey hemoglobin. From 6% to 13% of the amino acid side chains of these four proteins are seen in multiple, discrete conformations. Most common are flexible side chains on the molecular surface, but structural heterogeneity occasionally extends...
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Physicochemical properties of the plasma membrane have been shown to play an important role in cellular functionality. Among those properties, the molecular order of the lipids, or the lipid packing, is of high importance. Changes in lipid packing are believed to compartmentalize cellular signaling by initiating coalescence and conformational changes of proteins. A common way to infer membrane ...
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ژورنال
عنوان ژورنال: Protein Science
سال: 1998
ISSN: 0961-8368,1469-896X
DOI: 10.1002/pro.5560070526